Umod<urehr4> Chemically induced Allele Detail MGI Mouse (MGI:3712284)

Umod^urehr4
Chemically induced Allele Detail

Summary

Symbol:	Umod^urehr4
Name:	uromodulin; urea phenotype 4
MGI ID:	MGI:3712284
Synonyms:	HST001, Umod^A227T
Gene:	Umod Location: Chr7:119061931-119078485 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
Alliance:	Umod^urehr4 page

Mutation
origin

Strain of Origin:

C3HeB/FeJ

Mutation
description

Allele Type:		Chemically induced (ENU)
Mutation:		Single point mutation
		Mutation details: ENU mutagenesis induces a G to A transversion at nucleotide 871 in exon 3 (NM_009470) that results in an amino acid substitution of threonine for alanine at position 227 (A227T). (J:153895)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Umod Mutation:	5 strains or lines available

References

Original:	J:121470 Aigner B, et al., Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol. 2007 May;292(5):F1560-7
All:	7 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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